A newly discovered bone growth is believed to be the basis of a revolutionary new drug that will change osteoporosis medications, medical experts say, citing the discovery by the Georgia Health Sciences University graduate student Guodong Pan. This new discovery might dispel the recent study that suggests that current osteoporosis meds are no better than measured wine consumption.
The protein is called GILZ. It was originally discovered (along with Dr. XingMing Shi, a bone biologist at the GHSU Institute of Molecular Medicine and Genetics) as an alternative medication for treating rheumatoid arthritis. Nonetheless it has significant potential for treating other diseases involving bone brittleness. The normal drug of choice for treating rheumatoid arthritis is glucocorticoids, but these drugs have been known to cause osteoporosis in addition to reducing the body’s inflammatory response and leaving the body prone to bone loss.
Due to both bone and fat cells sharing the same biological precursor in mesemchymal stem cells, which may be made into both fat and bone cells for a person. The challenge then, for the researchers was to find a way to disrupt the body’s natural tendency to create fat and instead induce more bone production.
The result was finding that GILZ was not only responsible for mediating the immune response of the body (similar to glucocorticoids) but it also mediates bone formation as well. When overexpressed in lab mice this protein led to increased bone growth in mice. The way this works is that the protein inhibits fat production by regulating it and genes marked for its production. If this study proves successful, safe and confirmed for becoming into a medication that may be taken for treating arthritis but also potentially for osteoporosis.
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In Oct 12-15, Guodong Pan received the Young Investigator Award from the American Society for Bone and Mineral Research for his groundbreaking work in this field of study at the society’s annual meeting in Minneapolis. If you wish to read more about osteoporosis, fractures, arthritis and updates on Fosamax and other osteoporosis medication, read more articles on the settlement compensation for Fosamax on websites and resources online.
17 Oct 2012